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Ubiquitin-specific protease 28: the decipherment of its dual roles in cancer development

6 Mar 2023

Abstract excerpt

As significant posttranslational modifications, ubiquitination and deubiquitination, whose balance is modulated by ubiquitin-conjugating enzymes and deubiquitinating enzymes (DUBs), can regulate many biological processes, such as controlling cell cycle progression, signal transduction and transcriptional regulation. Belonging to DUBs, ubiquitin-specific protease 28 (USP28) plays an essential role in turning over...

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PMID: 36879346
DOI: 10.1186/s40164-023-00389-z

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