Article

RPA phosphorylation regulates DNA resection

2019-01-17

Abstract excerpt

Genetic recombination in all kingdoms of life initiates when helicases and nucleases process (resect) the free DNA ends to expose single-stranded (ss) DNA overhangs. Resection termination in bacteria is programmed by a DNA sequence but the mechanisms limiting resection in eukaryotes have remained elusive. Using single-molecule imaging of reconstituted human DNA repair factors, we identify a general mechanism that...

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Literature Corpus work: fc52114e-9053-548e-94e2-0c7046b39b57
DOI: 10.1101/517771

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