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Whole‑exome sequencing reveals Lewis lung carcinoma is a hypermutated Kras/Nras-mutant cancer with extensive regional mutation clusters in its genome.

Scientific reports - 2 Jan 2024

He Quan, Sun Cuirong, Pan Yuanjiang

Abstract excerpt

Lewis lung carcinoma (LLC), as a widely used preclinical cancer model, has still not been genetically and genomically characterized. Here, we performed a whole-exome sequencing analysis on the LLC cell line to elucidate its molecular characteristics and etiologies. Our data showed that LLC originated from a male mouse belonging to C57BL/6L (a transitional strain between C57BL/6J and C57BL/6N) and contains...

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Identifiers

PMID: 38167599
DOI: 10.1038/s41598-023-50703-2
PMCID: PMC10762126

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