Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Joint single cell DNA-seq and RNA-seq of gastric cancer cell lines reveals rules of in vitro evolution

14 Mar 2020

Abstract excerpt

Cancer cell lines are not homogeneous nor are they static in their genetic state and biological properties. Genetic, transcriptional and phenotypic diversity within cell lines contributes to the lack of experimental reproducibility frequently observed in tissue-culture-based studies. While cancer cell line heterogeneity has been generally recognized, there are no studies which quantify the number of clones that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32215369
DOI: 10.1093/nargab/lqaa016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Joint single cell DNA-seq and RNA-seq of gastric cancer cell lines reveals rules of in vitro evolutionPMID 32215369Read ↗

Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma.Semantic proximity Read ↗

Single-cell RNA sequencing to map tumor heterogeneity in gastric carcinogenesis paving roads to individualized therapySemantic proximity Read ↗

Deterministic evolution and stringent selection during pre-neoplasiaSemantic proximity Read ↗

Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer.Semantic proximity Read ↗

Integrated single-cell transcriptomic atlas of human gastric and colorectal tissues across diverse phenotypes.Semantic proximity Read ↗

Genetic and transcriptional evolution alters cancer cell line drug response.Semantic proximity Read ↗

Single cell genomic characterization reveals the cellular reprogramming of the gastric tumor microenvironmentSemantic proximity Read ↗

Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric CancerSemantic proximity Read ↗

Integrative single-cell multiomics analyses dissect molecular signatures of intratumoral heterogeneities and differentiation states of human gastric cancerSemantic proximity Read ↗

Cell-of-Origin Analysis of Metastatic Gastric Cancer Uncovers the Origin of Inherent Intratumor Heterogeneity and a Fundamental Prognostic SignatureSemantic proximity Read ↗

Pan-cancer single cell RNA-seq uncovers recurring programs of cellular heterogeneitySemantic proximity Read ↗

Dissecting the Single-Cell Transcriptome Network Underlying Gastric Premalignant Lesions and Early Gastric CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.