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Article

Deterministic evolution and stringent selection during preneoplasia.

Nature - 1 Jun 2023

Karlsson Kasper, Przybilla Moritz J, Kotler Eran, Khan Aziz, Xu Hang, Karagyozova Kremena, Sockell Alexandra, Wong Wing H, Liu Katherine, Mah Amanda, Lo Yuan-Hung, Lu Bingxin, Houlahan Kathleen E, Ma Zhicheng, Suarez Carlos J, Barnes Chris P, Kuo Calvin J, Curtis Christina

Abstract excerpt

The earliest events during human tumour initiation, although poorly characterized, may hold clues to malignancy detection and prevention1. Here we model occult preneoplasia by biallelic inactivation of TP53, a common early event in gastric cancer, in human gastric organoids. Causal relationships between this initiating genetic lesion and resulting phenotypes were established using experimental evolution in...

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Identifiers

PMID: 37258665
DOI: 10.1038/s41586-023-06102-8
PMCID: PMC10247377

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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