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Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy

3 Feb 2017

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) affects 1 in 500 individuals and is an important cause of arrhythmias and heart failure. Clinically, HCM is characterized as causing hypercontractility, and therapies are aimed toward controlling the hyperactive physiology. Mutations in the β-cardiac myosin comprise ~40% of genetic mutations associated with HCM, and the converter domain of myosin is a hotspot for HCM-causing...

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PMID: 28246639
DOI: 10.1126/sciadv.1601959

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