Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is a common genetic disorder characterized by left ventricular hypertrophy and cardiac hyper-contractility. Mutations in the β-cardiac myosin heavy chain gene (β- MyHC ) are a major cause of HCM, but the specific mechanistic changes to myosin function that lead to this disease remain incompletely understood. Predicting the severity of any β -MyHC mutation is hindered by a lack of...

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