Article

Calpain-2 mediates SARS-CoV-2 entry and represents a therapeutic target

2022-11-29

Abstract excerpt

<h4>ABSTRACT</h4> Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, much effort has been dedicated to identifying effective antivirals against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A number of calpain inhibitors show excellent antiviral activities against SARS-CoV-2 by targeting the viral main protease (M pro ), which plays an essential role in processing viral poly...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fc2e9f25-109e-5d70-967c-dc447c3d4da2
DOI: 10.1101/2022.11.29.518418

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Calpain-2 mediates SARS-CoV-2 entry and represents a therapeutic targetDOI 10.1101/2022.11.29.518418Read

Novel sites for Cathepsin L cleavage in SARS-CoV-2 spike guide treatment strategiesSemantic proximity Read

Identification of Potent Small Molecule Inhibitors of SARS-CoV-2 EntrySemantic proximity Read

Spike glycoprotein and host cell determinants of SARS-CoV-2 entry and cytopathic effectsSemantic proximity Read

SARS-CoV-2 Entry Inhibitors: Small Molecules and Peptides Targeting Virus or Host CellsSemantic proximity Read

A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in miceSemantic proximity Read

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential.Semantic proximity Read

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease InhibitorSemantic proximity Read

Anti-viral chimeric protein RetroMAD1™ potently block SARS-CoV-2 viral entry and propagationSemantic proximity Read

Structure, activity and inhibition of human TMPRSS2, a protease implicated in SARS-CoV-2 activationSemantic proximity Read

Metalloproteinase-dependent and TMPRSS2-independnt cell surface entry pathway of SARS-CoV-2 requires the furin-cleavage site and the S2 domain of spike proteinSemantic proximity Read

The roles of cellular protease interactions in viral infections and programmed cell death: a lesson learned from the SARS-CoV-2 outbreak and COVID-19 pandemicSemantic proximity Read

P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradationSemantic proximity Read