Article

Determination of Colistin Resistance in Gram-negative Bacteria by Four Phenotypic Assays and Inference of the Underlying Molecular Mechanisms

2021-05-05

Abstract excerpt

<h4>Background: </h4> Colistin is used against multi-drug resistant pathogens, yet resistance emerges either through dissemination of plasmid-mediated genes ( mcr ) or chromosomal mutation of genes involved in lipopolysaccharide synthesis (i.e. mgrB, phoPQ, pmrCAB). Phenotypic susceptibility testing is challenging due to poor diffusion of colistin in agar media, leading to an underestimation of resistance. We aime...

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Literature Corpus work: fc275fb6-6500-5815-971f-41f636e74aa2
DOI: 10.21203/rs.3.rs-460043/v1

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