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Article

Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo

22 May 2006

Abstract excerpt

Truncated tau protein is the characteristic feature of human sporadic Alzheimer's disease. We have identified truncated tau proteins conformationally different from normal healthy tau. Subpopulations of these structurally different tau species promoted abnormal microtubule assembly in vitro suggesting toxic gain of function. To validate pathological activity in vivo we expressed active form of human truncated tau...

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Identifiers

PMID: 16753151
DOI: 10.1016/j.febslet.2006.05.029

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