Article
Plasma levels of an N-terminal tau fragment predict Alzheimer's and neurodegenerative disease biomarkers in autosomal dominant Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jan 2026
Schultz Stephanie A, Rao Yiwen, Liu Lei, Ostaszewski Beth, Anderson Amirah K, Yau Wai-Ying Wendy, Shirzadi Zahra, Gordon Brian A, Hassenstab Jason, Morris John C, Perrin Richard J, Allegri Ricardo F, Barthélemy Nicolas R, Fox Nick, Day Gregory S, Jucker Mathias, Levey Allan I, Levin Johannes, Mori Hiroshi, Salloway Stephen, Schofield Peter, McDade Eric, Sperling Reisa A, Bateman Randall J, Selkoe Dennis J, Chhatwal Jasmeer P
Abstract excerpt
INTRODUCTION: Tau species lacking truncation of the N-terminal region, including plasma N-terminal tau fragment 1 (NT1), have been previously associated with cognitive decline, neurodegeneration, and tau pathology in late-onset sporadic Alzheimer's disease (AD). METHODS: Here, we examined cross-sectional and longitudinal plasma NT1 as a possible predictor of cognitive, clinical, and core AD biomarker trajectories...
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