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Article

Truncation of tau at E391 promotes early pathologic changes in transgenic mice.

Journal of neuropathology and experimental neurology - 1 Nov 2011

McMillan Pamela J, Kraemer Brian C, Robinson Linda, Leverenz James B, Raskind Murray, Schellenberg Gerard

Abstract excerpt

Proteolytic cleavage of tau at glutamic acid 391 (E391) is linked to the pathogenesis of Alzheimer disease (AD). This C-terminal-truncated tau species exists in neurofibrillary tangles and abnormal neurites in the brains of AD patients and may potentiate tau polymerization. We generated a mouse model that expresses human tau truncated at E391 to begin to elucidate the role of this C-terminal-truncated tau species...

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Identifiers

PMID: 22002427
DOI: 10.1097/NEN.0b013e31823557fb
PMCID: PMC3237612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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