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Myeloid Cell Glucocorticoid, Not Mineralocorticoid Receptor Signaling, Contributes to Salt-Sensitive Hypertension in Humans via Cortisol

2024-06-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Salt sensitivity of blood pressure (SSBP) is an independent risk factor for cardiovascular morbidity and mortality, yet the etiology is poorly understood. We previously found that serum/glucocorticoid-regulated kinase 1 (SGK1) and epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel (ENaC)-dependent sodium entry into monocyte-derived antigen-presenting cells (...

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Literature Corpus work
fbefd18a-83d4-5632-a213-265bb041179f
DOI
10.1101/2024.06.10.598374
Open publication

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Myeloid Cell Glucocorticoid, Not Mineralocorticoid Receptor Signaling, Contributes to Salt-Sensitive Hypertension in Humans via CortisolDOI 10.1101/2024.06.10.598374
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