Article
Sodium activates human monocytes via the NADPH oxidase and isolevuglandin formation.
Cardiovascular research - 23 Apr 2021
Ruggeri Barbaro Natalia, Van Beusecum Justin, Xiao Liang, do Carmo Luciana, Pitzer Ashley, Loperena Roxana, Foss Jason D, Elijovich Fernando, Laffer Cheryl L, Montaniel Kim R, Galindo Cristi L, Chen Wei, Ao Mingfang, Mernaugh Raymond L, Alsouqi Aseel, Ikizler Talat A, Fogo Agnes B, Moreno Heitor, Zhao Shilin, Davies Sean S, Harrison David G, Kirabo Annet
Abstract excerpt
AIMS: Prior studies have focused on the role of the kidney and vasculature in salt-induced modulation of blood pressure; however, recent data indicate that sodium accumulates in tissues and can activate immune cells. We sought to examine mechanisms by which salt causes activation of human monocytes both in vivo and in vitro. METHODS AND RESULTS: To study the effect of salt in human monocytes, monocytes were...
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