Article

An unusual MHC molecule generates protective CD8+ T cell responses to chronic infection

2020-02-04

Abstract excerpt

The CD8+ T cell response to the intracellular parasite Toxoplasma gondii varies dramatically between mouse strains, resulting in differences in control of the parasite. Protection in BALB/c mice can be attributed to an unusually strong and protective MHC-1 L d -restricted CD8+ T cell response directed against a peptide derived from the parasite antigen GRA6. The MHC-1 L d molecule has limited peptide binding co...

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Literature Corpus work: fbe09674-ba53-577e-b902-f02f76ec1e45
DOI: 10.1101/2020.02.03.932848

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