Back to search

Article

Single-cell resolution map of innate-like lymphocyte response to <i>Francisella tularensis</i> infection reveals MAIT cells’ role in protection from tularemia-like disease

2024-10-06

Abstract excerpt

<h4>ABSTRACT</h4> Early immune dynamics during the initiation of fatal tularemia caused by Francisella tularensis infection remain unknown. Unto that end, we generated a transcriptomic map at single-cell resolution of the innate-like lymphocyte responses to F. tularensis live vaccine strain (LVS) infection of mice. We found that both interferon-γ-producing type 1 and interleukin-17-producing type 3 innate-like...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d8a6afb5-3fbc-5a30-96e5-830223e7b1b1
DOI
10.1101/2024.10.04.616759
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Single-cell resolution map of innate-like lymphocyte response to <i>Francisella tularensis</i> infection reveals MAIT cells’ role in protection from tularemia-like diseaseDOI 10.1101/2024.10.04.616759
Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection.Semantic proximity
Activation and <i>in vivo</i> evolution of the MAIT cell transcriptome in mice and humans reveals diverse functionalitySemantic proximity
Selective Activation of Macrophage Innate Signaling Pathways and Inflammatory Responses to <i>Orientia tsutsugamushi</i> Karp and Gilliam StrainsSemantic proximity
Clinical isolates of <i>Mycobacterium avium</i> complex reveal an <i>M. intracellulare</i> -associated IL-17/neutrophilic pulmonary immune program in a murine disease modelSemantic proximity
Innate Lymphoid Cells in Response to Intracellular Pathogens: Protection Versus ImmunopathologySemantic proximity
A genome-wide innateness gradient defines the functional state of human innate T cellsSemantic proximity
The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 InfectionSemantic proximity
γδ T cells: first line of defense and beyond.Semantic proximity
Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseasesSemantic proximity
Unique B Cell and Germinal Center Responses in Mice with Severe versus Mild <i>Orientia tsutsugamushi</i> InfectionSemantic proximity
Unique properties of tissue-resident memory T cells in the lungs: implications for COVID-19 and other respiratory diseasesSemantic proximity
Cell biology and molecular ecology of<i>Francisella tularensis</i>Semantic proximity
Select a neighboring publication to make it the new centre.