Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Parasite Stage–Specific Recognition of Endogenous <i>Toxoplasma gondii</i> –Derived CD8 <sup>+</sup> T Cell Epitopes

15 Oct 2008

Abstract excerpt

BACKGROUND: BALB/c mice control infection with the obligate intracellular parasite Toxoplasma gondii and develop a latent chronic infection in the brain, as do immunocompetent humans. Interferon-gamma-producing CD8+ T cells provide essential protection against T. gondii infection, but the epitopes recognized have so far remained elusive. METHODS: We employed caged major histocompatibility complex molecules to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Legionella and Acanthamoeba research
Share to Toxoplasma gondii Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18922097
DOI: 10.1086/593019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Parasite Stage–Specific Recognition of Endogenous <i>Toxoplasma gondii</i> –Derived CD8 <sup>+</sup> T Cell EpitopesPMID 18922097Read ↗

Location of the CD8 T Cell Epitope within the Antigenic Precursor Determines Immunogenicity and Protection against the Toxoplasma gondii ParasiteSemantic proximity Read ↗

Early immune responses and parasite tissue distribution in mice experimentally infected with oocysts of either archetypal or non-archetypal genotypes of Toxoplasma gondii.Semantic proximity Read ↗

The role of MHC haplotypes H2d/H2b in mouse resistance/susceptibility to cyst formation is influenced by the lineage of infective Toxoplasma gondii strain.Semantic proximity Read ↗

Host immune responses to Toxoplasma gondiiSemantic proximity Read ↗

Dense granule protein 3 of Toxoplasma gondii plays a crucial role in the capability of the tissue cysts of the parasite to persist in the presence of anti-cyst CD8+ T cells during the chronic stage of infectionSemantic proximity Read ↗

Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans.Semantic proximity Read ↗

Hypermigration of macrophages through the concerted action of GRA effectors on NF-κB/p38 signaling and host chromatin accessibility potentiates <i>Toxoplasma</i> disseminationSemantic proximity Read ↗

An unusual MHC molecule generates protective CD8+ T cell responses to chronic infectionSemantic proximity Read ↗

Immunology of<i>Toxoplasma gondii</i>Semantic proximity Read ↗

Galectin-3 and Galectin-9 May Differently Regulate the Expressions of Microglial M1/M2 Markers and T Helper 1/Th2 Cytokines in the Brains of Genetically Susceptible C57BL/6 and Resistant BALB/c Mice Following Peroral Infection With Toxoplasma gondii.Semantic proximity Read ↗

The lectin-specific activity of <i>Toxoplasma gondii</i> microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune primingSemantic proximity Read ↗

Identification of two alleles in the GRA4 locus of Toxoplasma gondii determining a differential epitope which allows discrimination of type I versus type II and III strains.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.