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Article

Exacerbated susceptibility to infection-stimulated immunopathology in CD1d-deficient mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2005

Smiley Stephen T, Lanthier Paula A, Couper Kevin N, Szaba Frank M, Boyson Jonathan E, Chen Wangxue, Johnson Lawrence L

Abstract excerpt

Mice lacking functional CD1d genes were used to study mechanisms of resistance to the protozoan parasite Toxoplasma gondii. Wild-type (WT) BALB/c mice, CD1d-deficient BALB/c mice, and WT C57BL/6 mice all survived an acute oral infection with a low dose of mildly virulent strain ME49 T. gondii cysts. In contrast, most CD1d-deficient C57BL/6 mice died within 2 wk of infection. Despite having parasite burdens that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intestinal Diseases, Parasitic

Share to Receptors, Antigen, T-Cell, alpha-beta

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Source

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Identifiers

PMID: 15944296
DOI: 10.4049/jimmunol.174.12.7904
PMCID: PMC3010175

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