Article

Structural basis for the inhibition of coronaviral main proteases by PF-00835231

2024-04-22

Abstract excerpt

The main protease (M pro ) of coronaviruses plays a key role in viral replication, thus serving as a hot target for drug design. It has been proven that PF-00835231 is promising inhibitor of SARS-CoV-2 M pro . Here, we report the inhibition potency of PF-00835231 against SARS-CoV-2 M pro and seven M pro mutants (G15S, M49I, Y54C, K90R, P132H, S46F, and V186F) from SARS-CoV-2 variants. The results confirm that...

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Literature Corpus work: fbdd39a7-0342-5734-a899-1efed29aa3d5
DOI: 10.1101/2024.04.22.590578

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