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Is PF-00835231 a Pan-SARS-CoV-2 Mpro Inhibitor? A Comparative Study

17 Mar 2021

Abstract excerpt

The COVID-19 outbreak continues to spread worldwide at a rapid rate. Currently, the absence of any effective antiviral treatment is the major concern for the global population. The reports of the occurrence of various point mutations within the important therapeutic target protein of SARS-CoV-2 has elevated the problem. The SARS-CoV-2 main protease (Mpro) is a major therapeutic target for new antiviral designs....

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PMID: 33802860
DOI: 10.3390/molecules26061678

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