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Article

Structural basis for the inhibition of coronaviral main proteases by PF-00835231.

Acta biochimica et biophysica Sinica - 29 Jul 2024

Zhou Xuelan, Lu Xiaolu, Lin Cheng, Zou Xiaofang, Li Wenwen, Zeng Xiangyi, Wang Jie, Zeng Pei, Wang Weiwei, Zhang Jin, Jiang Haihai, Li Jian

Abstract excerpt

The main protease (M pro) of coronaviruses plays a key role in viral replication, thus serving as a hot target for drug design. PF-00835231 is a promising inhibitor of SARS-CoV-2 M pro. Here, we report the inhibitory potency of PF-00835231 against SARS-CoV-2 M pro and seven M pro mutants (G15S, M49I, Y54C, K90R, P132H, S46F, and V186F) from SARS-CoV-2 variants. The results confirm that PF-00835231 has...

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Coronavirus 3C Proteases
Crystallography, X-Ray
Indoles
Leucine
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Domains

Structure-Activity Relationship

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Identifiers

PMID: 39076076
DOI: 10.3724/abbs.2024122
PMCID: PMC11693862

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