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SARS-CoV-2 main protease (M-pro) mutational profiling: An insight into mutation coldspots.

Computers in biology and medicine - 1 Jan 2025

Garcia-Segura Pol, Llop-Peiró Ariadna, Novau-Ferré Nil, Mestres-Truyol Júlia, Saldivar-Espinoza Bryan, Pujadas Gerard, Garcia-Vallvé Santiago

Abstract excerpt

SARS-CoV-2 and the COVID-19 pandemic have marked a milestone in the history of scientific research worldwide. To ensure that treatments are successful in the mid-long term, it is crucial to characterize SARS-CoV-2 mutations, as they might lead to viral resistance. Data from >5,700,000 SARS-CoV-2 genomes available at GISAID was used to report SARS-CoV-2 mutations. Given the pivotal role of its main protease...

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PMID: 39531923
DOI: 10.1016/j.compbiomed.2024.109344

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