Article

Dysregulation of the p16–CDK6 axis characterizes HPV-unrelated p16-positive oropharyngeal carcinoma

2026-08-17

Abstract excerpt

Human papillomavirus (HPV)-related and HPV-unrelated oropharyngeal squamous cell carcinomas (OPCs) are distinct entities with different clinical outcomes. While p16 immunohistochemistry (IHC) is widely used as a surrogate marker for HPV-driven OPC, a subset of HPV-unrelated OPCs also overexpress p16, and the biological basis of this discordance remains unclear. Here, we performed integrated clinicopathological, tr...

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Literature Corpus work: fbd3406d-0e29-5b63-bd1b-034406b96336
DOI: 10.64898/2026.08.17.743010

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