Article
HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients.
Journal of the National Cancer Institute - 1 Jun 2016
Castellsagué Xavier, Alemany Laia, Quer Miquel, Halec Gordana, Quirós Beatriz, Tous Sara, Clavero Omar, Alòs Llúcia, Biegner Thorsten, Szafarowski Tomasz, Alejo Maria, Holzinger Dana, Cadena Enrique, Claros Edith, Hall Gillian, Laco Jan, Poljak Mario, Benevolo Maria, Kasamatsu Elena, Mehanna Hisham, Ndiaye Cathy, Guimerà Núria, Lloveras Belen, León Xavier, Ruiz-Cabezas Juan C, Alvarado-Cabrero Isabel, Kang Chang-Suk, Oh Jin-Kyoung, Garcia-Rojo Marcial, Iljazovic Ermina, Ajayi Oluseyi F, Duarte Flora, Nessa Ashrafun, Tinoco Leopoldo, Duran-Padilla Marco A, Pirog Edyta C, Viarheichyk Halina, Morales Hesler, Costes Valérie, Félix Ana, Germar Maria Julieta V, Mena Marisa, Ruacan Arzu, Jain Asha, Mehrotra Ravi, Goodman Marc T, Lombardi Luis Estuardo, Ferrera Annabelle, Malami Sani, Albanesi Estela I, Dabed Pablo, Molina Carla, López-Revilla Rubén, Mandys Václav, González Manuel E, Velasco Julio, Bravo Ignacio G, Quint Wim, Pawlita Michael, Muñoz Nubia, de Sanjosé Silvia, Xavier Bosch F
Abstract excerpt
BACKGROUND: We conducted a large international study to estimate fractions of head and neck cancers (HNCs) attributable to human papillomavirus (HPV-AFs) using six HPV-related biomarkers of viral detection, transcription, and cellular transformation. METHODS: Formalin-fixed, paraffin-embedded cancer tissues of the oral cavity (OC), pharynx, and larynx were collected from pathology archives in 29 countries. All...
Read the complete abstract on PubMed