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Frequent HPV-independent p16/INK4A overexpression in head and neck cancer.

Oral oncology - 1 Aug 2018

Lechner Matt, Chakravarthy Ankur R, Walter Vonn, Masterson Liam, Feber Andrew, Jay Amrita, Weinberger Paul M, McIndoe Richard A, Forde Cillian T, Chester Kerry, Kalavrezos Nicholas, O'Flynn Paul, Forster Martin, Jones Terry M, Vaz Francis M, Hayes D Neil, Fenton Tim R

Abstract excerpt

OBJECTIVES: p16INK4A (p16) is the most widely used clinical biomarker for Human Papillomavirus (HPV) in head and neck squamous cell cancer (HNSCC). HPV is a favourable prognostic marker in HNSCC and is used for patient stratification. While p16 is a relatively accurate marker for HPV within the oropharynx, recent reports suggest it may be unsuitable for use in other HNSCC subsites, where a smaller proportion of...

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PMID: 30098776
DOI: 10.1016/j.oraloncology.2018.06.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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