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Using digital spatial profiling to analyse onco-immune-related gene expression within oropharyngeal tumours in relation to HPV and p16 status

2023-11-17

Abstract excerpt

Human Papilloma virus (HPV)-mediated oropharyngeal cancer (OPC) has significantly better prognosis compared with HPV-negative, stimulating interest in treatment de-intensification approaches to reduce long-term sequelae. Routine clinical testing frequently utilises immunohistochemistry to detect upregulation of p16 protein as a surrogate marker of HPV-mediation. However, this does not detect discordant HPV+/p16-ca...

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Literature Corpus work
21092fd9-1bbf-509e-9192-63f54f12ea53
DOI
10.1101/2023.11.17.23298621
Open publication

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Using digital spatial profiling to analyse onco-immune-related gene expression within oropharyngeal tumours in relation to HPV and p16 statusDOI 10.1101/2023.11.17.23298621
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