Genomic Enrichment and Functional Impact of TP53 and CYLD Alterations in Recurrent and Metastatic HPV-Associated Head and Neck Cancer.

doi:10.1158/1078-0432.CCR-25-3972

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Article

Genomic Enrichment and Functional Impact of TP53 and CYLD Alterations in Recurrent and Metastatic HPV-Associated Head and Neck Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2026

Prasad Manu, Cheng Alex T, Mayer Marcel, Jansen Louis, Koh Elizabeth, Nadeem Zaineb, Sivan Pillai Gopika, Vos Joris, Kuo Fengshen, Zhao Karena, Sfreddo Hannah J, Lee Andrew, Chen Siqi, Schloss Jennifer, Deng Xinzhu, Jain Swati, Muldoon Daniel, Bandlamudi Chaitanya, Klussmann Jens Peter, Ow Thomas J, Ho Alan L, Lee Nancy Y, Riaz Nadeem, Wong Richard J, Ganly Ian, Katabi Nora, Morris Luc G T

Abstract excerpt

PURPOSE: Recurrent and metastatic human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (R/M HPV+ HNSCC) remains largely incurable, with genetic drivers incompletely defined. We profiled the genetic landscape of R/M HPV+ HNSCC and functionally characterized genetic alterations strongly enriched in this cancer type. EXPERIMENTAL DESIGN: We identified genetic alterations uniquely enriched in...

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Identifiers

PMID: 41603724
DOI: 10.1158/1078-0432.CCR-25-3972
PMCID: PMC12959380

Genes

CYLD
TP53

Variants

Provenance

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