Article
Discovery of chirally dependent protein modifications by D- and L-2-hydroxyglutarates.
Nature chemistry - 1 Jun 2026
Zhang Zheng, Liu Yi-Kai, Luo Zhuojun, Wu Meng-Ju, Evans Claudia N, Qu Zihan, Xue Fanglei, Wang Zhijian, Stanciu Lia, Zhang Zhong-Yin, Parkinson Elizabeth I, Bardeesy Nabeel, Andy Tao W
Abstract excerpt
Mutations in isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) are common in multiple types of human cancer and cause accumulation of the oncometabolite D-2-hydroxyglutarate (D2HG) instead of α-ketoglutarate, driving cancers like gliomas and acute myeloid leukaemia by blocking cell differentiation and promoting tumour growth. Here we discovered protein O-2-hydroxyglutarylation by D2HG using chemical proteomics and...
Topics
Join the communities discussing this publication.