Article

Methylmalonic acid compromises mitochondrial respiration and reduces the expression of markers of differentiation in SH-SY5Y human neuroblastoma cells

2020-08-24

Abstract excerpt

<h4>ABSTRACT</h4> Methylmalonic acidemia is a rare metabolic disorder characterized by the accumulation of methylmalonic acid (MMA) and alternatives metabolites which is caused by the deficient activity of L-methylmalonyl-CoA mutase or its cofactor 5-deoxyadenosylcobalamin (AdoCbl). The brain is one of the affected tissues by the accumulation of this metabolite in patients. The neurologic symptoms commonly appear...

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Literature Corpus work: b71b7c96-c4f2-56fc-913e-316912291fa8
DOI: 10.1101/2020.08.24.265157

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