Article
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome.
Proceedings of the National Academy of Sciences of the United States of America - 22 Feb 2011
Reitman Zachary J, Jin Genglin, Karoly Edward D, Spasojevic Ivan, Yang Jian, Kinzler Kenneth W, He Yiping, Bigner Darell D, Vogelstein Bert, Yan Hai
Abstract excerpt
Point mutations of the NADP(+)-dependent isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) occur early in the pathogenesis of gliomas. When mutated, IDH1 and IDH2 gain the ability to produce the metabolite (R)-2-hydroxyglutarate (2HG), but the downstream effects of mutant IDH1 and IDH2 proteins or of 2HG on cellular metabolism are unknown. We profiled >200 metabolites in human oligodendroglioma (HOG) cells to...
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