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HTLV-1–infected T cells contain a single integrated provirus in natural infection

7 Sept 2012

Abstract excerpt

Human T lymphotropic virus type 1 (HTLV-1) appears to persist in the chronic phase of infection by driving oligoclonal proliferation of infected T cells. Our recent high-throughput sequencing study revealed a large number (often > 10(4)) of distinct proviral integration sites of HTLV-1 in each host that is greatly in excess of previous estimates. Here we use the highly sensitive, quantitative high-throughput...

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PMID: 22955925
DOI: 10.1182/blood-2012-07-445593

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