Article

Spatial transcriptomics of T and B cell receptors uncovers lymphocyte clonal dynamics in human tissue

2022-11-24

Abstract excerpt

The spatial distribution of lymphocyte clones within tissues is critical to their development, selection, and expansion. We have developed Spatial Transcriptomics of VDJ sequences (Spatial VDJ), which maps immunoglobulin and TR antigen receptors in human tissue sections. Spatial VDJ captures lymphocyte clones matching canonical T, B, and plasma cell distributions in tissues and amplifies clonal sequences confirmed...

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Literature Corpus work: fb9af814-8ca5-52f4-a126-e61719a2ec19
DOI: 10.1101/2022.11.22.516865

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