Article

circVDJ-seq for T cell clonotype detection in single-cell and spatial multi-omics

2025-09-18

Abstract excerpt

Monitoring T cell repertoires in human tissues provides important insights into immune response mechanisms in cancer, infectious diseases, and autoimmunity. However, retrieving VDJ information from single-cell and spatial transcriptomics workflows with 3’-barcoding of cDNA remains resource-intensive or requires specialized sequencing equipment. Here, we introduce circVDJ-seq for simplified and cost-efficient T cel...

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Identifiers and source

Literature Corpus work: d933842d-9088-58f6-a6b6-eeffa9766116
DOI: 10.1101/2025.09.16.675546

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