Article

Altered patterning of trisomy 21 interneuron progenitors

2020-02-19

Abstract excerpt

<h4>SUMMARY</h4> Individuals with Down syndrome (DS, Ts21), the most common genetic cause of intellectual disability, have smaller brains that reflect fewer neurons at pre- and post-natal stages, implicating impaired neurogenesis during development. Our stereological analysis of adult DS cortex indicates a reduction of calretinin expressing interneurons. Using Ts21 human induced pluripotent stem cells (iPSCs) and...

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Literature Corpus work: fb78a102-be29-5286-8f1f-4f42ac25c6c8
DOI: 10.1101/2020.02.18.951756

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