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Article

Altered patterning of trisomy 21 interneuron progenitors

26 May 2022

Abstract excerpt

Individuals with Down syndrome (DS; Ts21), the most common genetic cause of intellectual disability, have smaller brains that reflect fewer neurons at pre- and post-natal stages, implicating impaired neurogenesis during development. Our stereological analysis of adult DS cortex indicates a reduction of calretinin-expressing interneurons. Using Ts21 human induced pluripotent stem cells (iPSCs) and isogenic...

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PMID: 35623352
DOI: 10.1016/j.stemcr.2022.05.001

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