Article

BAP1 and YY1 regulate expression of death receptors in malignant pleural mesothelioma

2020-08-31

Abstract excerpt

Malignant pleural mesothelioma (MPM) is a rare, aggressive, and incurable cancer arising from the mesothelial lining of the lungs with few treatment options. We recently reported loss of function of the nuclear deubiquitinase BRCA associated protein-1 (BAP1), a frequent event in MPM, is associated with sensitivity to tumour necrosis factor-related apoptosis-inducing ligand (TRAIL). As a potential underlying mechan...

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Literature Corpus work: fb6160d5-6d6f-5ee2-bcf0-99c2672c263e
DOI: 10.1101/2020.08.31.274951

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