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Article

BAP1 and YY1 regulate expression of death receptors in malignant pleural mesothelioma.

The Journal of biological chemistry - 1 Nov 2021

Ishii Yuki, Kolluri Krishna K, Pennycuick Adam, Zhang Xidan, Nigro Ersilia, Alrifai Doraid, Borg Elaine, Falzon Mary, Shah Khalid, Kumar Neelam, Janes Sam M

Abstract excerpt

Malignant pleural mesothelioma (MPM) is a rare, aggressive, and incurable cancer arising from the mesothelial lining of the pleura, with few available treatment options. We recently reported that loss of function of the nuclear deubiquitinase BRCA1-associated protein 1 (BAP1), a frequent event in MPM, is associated with sensitivity to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated...

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Share to Cell Line, Tumor
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mesothelioma, Malignant

Share to Receptors, TNF-Related Apoptosis-Inducing Ligand

Share to TNF-Related Apoptosis-Inducing Ligand

Share to Tumor Suppressor Proteins

Share to Ubiquitin Thiolesterase

Share to YY1 Transcription Factor

Source

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Identifiers

PMID: 34597666
DOI: 10.1016/j.jbc.2021.101223
PMCID: PMC8545693

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BAP1 and YY1 regulate expression of death receptors in malignant pleural mesothelioma.PMID 34597666Read ↗

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