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Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

18 Jan 2018

Abstract excerpt

Malignant mesothelioma (MM) is poorly responsive to systemic cytotoxic chemotherapy and invariably fatal. Here we describe a screen of 94 drugs in 15 exome-sequenced MM lines and the discovery of a subset defined by loss of function of the nuclear deubiquitinase BRCA associated protein-1 (BAP1) that demonstrate heightened sensitivity to TRAIL (tumour necrosis factor-related apoptosis-inducing ligand). This...

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PMID: 29345617
DOI: 10.7554/elife.30224

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