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BAP1 regulates different mechanisms of cell death

19 Nov 2018

Abstract excerpt

The ubiquitin carboxyl terminal BAP1 is a member of deubiquitinating enzymes superfamily, which are responsible for coordinating ubiquitin-signaling processes through the removal of ubiquitin from protein substrates. Studies of families with high incidence of mesothelioma 1 , 2 , led to the discovery that all affected family members carried heterozygous BAP1 mutations (BAP1 +/− ) 3 , a condition that was named...

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PMID: 30455474
DOI: 10.1038/s41419-018-1206-5

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