Article

Neural crest induction requires SALL4-mediated BAF recruitment to lineage specific enhancers

2025-06-10

Abstract excerpt

<h4>ABSTRACT</h4> Neural crest induction begins early during neural plate formation, requiring precise transcriptional control to activate lineage-specific enhancers. Here, we demonstrate that SALL4, a transcription factor associated with syndromes featuring craniofacial anomalies, plays a critical role in early cranial neural crest (CNCC) specification. Using SALL4 -het-KO human iPSCs to model clinical haploins...

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Literature Corpus work: 52ac9675-b29d-5f02-96fb-c400d5aff12d
DOI: 10.1101/2025.06.10.658805

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