Article

Looping specificity of Polycomb response elements requires GAF and a combinatorial code of looping factors

2025-11-29

Abstract excerpt

Chromatin looping between cis -regulatory elements is essential for precise developmental gene expression, and its disruption is frequently linked to disease. Polycomb Response Elements (PREs) are specialized tethering elements that mediate chromatin loops and are bound by transcription factors like GAGA-associated factor (GAF), contributing to the recruitment of Polycomb group (PcG) proteins. While both PcG prot...

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Literature Corpus work: fb3c9866-0e07-561c-bdd8-5e15ddfb3c8a
DOI: 10.1101/2025.11.28.691166

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