Reproducing human and cross-species drug toxicities using a Liver-Chip.

doi:10.1126/scitranslmed.aax5516

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Article

Reproducing human and cross-species drug toxicities using a Liver-Chip.

Science translational medicine - 6 Nov 2019

Jang Kyung-Jin, Otieno Monicah A, Ronxhi Janey, Lim Heng-Keang, Ewart Lorna, Kodella Konstantia R, Petropolis Debora B, Kulkarni Gauri, Rubins Jonathan E, Conegliano David, Nawroth Janna, Simic Damir, Lam Wing, Singer Monica, Barale Erio, Singh Bhanu, Sonee Manisha, Streeter Anthony J, Manthey Carl, Jones Barry, Srivastava Abhishek, Andersson Linda C, Williams Dominic, Park Hyoungshin, Barrile Riccardo, Sliz Josiah, Herland Anna, Haney Suzzette, Karalis Katia, Ingber Donald E, Hamilton Geraldine A

Abstract excerpt

Nonclinical rodent and nonrodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans, contributing to drug failures in the clinic. Here, we applied microengineered Organs-on-Chips technology to design a rat, dog, and human Liver-Chip containing species-specific primary hepatocytes interfaced with liver sinusoidal endothelial...

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Identifiers

PMID: 31694927
DOI: 10.1126/scitranslmed.aax5516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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