Article

Transcriptomic mapping of the inter-individual variability of cellular stress response activation in primary human hepatocytes

2021-08-28

Abstract excerpt

<h4>Background & Aims</h4> One of the early key events of drug-induced liver injury (DILI) is the activation of adaptive stress responses, a cellular mechanism to overcome stress. Given the diversity of DILI outcomes and lack in understanding of population variability, we mapped the inter-individual variability in stress response activation to improve DILI prediction. <h4>Approach & Results</h4> High-throughput...

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Literature Corpus work: 60feb0f8-d591-587f-a851-50b824fdba47
DOI: 10.1101/2021.08.26.457742

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