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ANIMAL MODELS OF HUMAN DISEASE IN DRUG SAFETY ASSESSMENT

1 Jan 2003

Abstract excerpt

Animal models of human disease have been widely used in drug discovery, but they are rarely utilized in toxicological research and screening (except for transgenic models in carcinogenicity testing). Although genetic and/or acquired pathophysiological alterations associated with a particular disease may greatly exacerbate toxic responses to drugs in certain patient subsets, these pre-existing pathological...

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PMID: 12974604
DOI: 10.2131/jts.28.109

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