Hepatic cellular stress response pathways exhibit species differences in basal and inducible activity

Abstract excerpt

Cellular stress response pathways such as the NRF2 oxidative stress response, endoplasmic reticulum (ER) stress response and macroautophagy afford protection against many forms of drug toxicity, including the liver toxicity associated with the formation of reactive drug metabolites. To maximise the translatability of preclinical toxicology studies, an understanding of the relative hepatic stress response capacitie...

Topics

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• Biomarkers
• Chemical and Drug Induced Liver Injury
• Cytochrome P-450 Enzyme System
• Disease Models, Animal
• Drug Discovery
• Drug-Induced Hepatotoxicity and Protection
• Drug Transport and Resistance Mechanisms
• Pharmacogenetics and Drug Metabolism

Identifiers and source

Literature Corpus work

07a1c8cc-d095-54d9-b801-d581024bbcb4

DOI

10.1101/2025.09.22.677731