Article

Hyperosmotic stress induces downstream-of-gene transcription and alters the RNA Polymerase II interactome despite widespread transcriptional repression

2020-07-02

Abstract excerpt

<h4>Summary</h4> Stress-induced readthrough transcription results in the synthesis of thousands of downstream-of-gene (DoG) containing transcripts. The mechanisms underlying DoG formation during cellular stress remain unknown. Nascent transcription profiles during DoG induction in human cell lines using TT-TimeLapse-seq revealed that hyperosmotic stress induces widespread transcriptional repression. Yet, DoGs are...

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Literature Corpus work: fb312c46-5b27-5c4f-b696-a9d3979bbda6
DOI: 10.1101/2020.06.30.178103

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