Article

SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling

2021-12-13

Abstract excerpt

<h4>Summary</h4> Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction within the lung as well as in distal organs. While it is appreciated that an exaggerated inflammatory response is associated with barrier dysfunction, the triggers of this pathology are unclear. Here, we report that cell-intrinsic interactions between the Spike (S) glycoprotein of SARS-CoV-2 and epithelial/endotheli...

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Literature Corpus work: fb28d71a-2fa5-5f10-9282-261b7257d7c0
DOI: 10.1101/2021.12.10.472112

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