Article

IL-1β and TNF drive endothelial dysfunction and coagulopathy in acute COVID-19

2026-03-25

Abstract excerpt

Vascular dysfunction and coagulopathy are hallmarks of severe COVID-19. How SARS-CoV-2 infection drives endothelial dysfunction, despite the virus not infecting or replicating in endothelial cells, remains controversial. Here, we used an in vitro co-culture model of the human pulmonary epithelial-endothelial cell barrier to investigate which inflammatory mediators drive endothelial dysfunction during SARS-CoV-2 i...

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Literature Corpus work: 1a286fbb-f1b7-51df-9f1d-a1ae5d1615e0
DOI: 10.64898/2026.03.21.713333

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