Article
The D405N Mutation in the Spike Protein of SARS-CoV-2 Omicron BA.5 Inhibits Spike/Integrins Interaction and Viral Infection of Human Lung Microvascular Endothelial Cells.
Viruses - 24 Jan 2023
Bugatti Antonella, Filippini Federica, Messali Serena, Giovanetti Marta, Ravelli Cosetta, Zani Alberto, Ciccozzi Massimo, Caruso Arnaldo, Caccuri Francesca
Abstract excerpt
Severe COVID-19 is characterized by angiogenic features, such as intussusceptive angiogenesis, endothelialitis, and activation of procoagulant pathways. This pathological state can be ascribed to a direct SARS-CoV-2 infection of human lung ECs. Recently, we showed the capability of SARS-CoV-2 to infect ACE2-negative primary human lung microvascular endothelial cells (HL-mECs). This occurred through the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.