Article

Inflammation in the COVID-19 airway is due to inhibition of CFTR signaling by the SARS-CoV-2 Spike protein

2022-01-20

Abstract excerpt

<h4>Background</h4> SARS-CoV-2-contributes to sickness and death in COVID-19 patients partly by inducing a hyper-proinflammatory immune response in the host airway. This hyper- proinflammatory state involves activation of signaling by NFκB and ENaC, and expression of high levels of cytokines and chemokines. Post-infection inflammation may contribute to “Long COVID”, and there are long term consequences for acute...

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Literature Corpus work: 1b51fd83-c9cf-5eb9-be8e-58363b4b151e
DOI: 10.1101/2022.01.18.476803

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